Zhang Laboratory Organic Synthesis for Drug Discovery

Supervised work

17) C. Zhang,* S. Dong, M. C. Dietl, M. Rudolph, X. Zhang, K. Hong, W. Yi, A. S. K. Hashmi,* X. Xu* Chem Catal. 5, 101163 (2025): Practical and modular cycloadditions of in-situ-formed exocyclic vinylcarbenes

16) C. Zhang, K. Hong, S. Dong, M. Liu, M. Rudolph, M. C. Dietl, J. Yin, W. Hu, A. S. K. Hashmi,* X. Xu* ACS Catal. 13, 4646 (2023): Generation and Utility of Cyclic Dienyl Gold Carbene Intermediates

15) C. Zhang,* Q. Chen, L. Wang, Q. Sun, M. Rudolph, F. Rominger, A. S. K. Hashmi* Sci. China Chem. 65, 1338 (2022): Practical and Modular Construction of Benzo[c]phenanthridine Compounds

14) C. Zhang, Q. Sun, M. Rudolph, F. Rominger, A. S. K. Hashmi,* ACS Catal. 11, 15203 (2021): Gold-Catalyzed Regiodivergent Annulations of Diazo-Alkynes Controlled by Et3N(HF)3

13) C. Zhang, K. Hong, C. Pei, S. Zhou, W. Hu, A. S. K. Hashmi,* X. Xu* Nat. Commun. 12, 1182 (2021): Gold(I)-catalyzed intramolecular cyclization/intermolecular cycloaddition cascade as a fast track to polycarbocycles and mechanistic insights

12) C. Zhang, H. Li, C. Pei, L. Qiu, W. Hu,* X. Bao,* X. Xu* ACS Catal. 9, 2440 (2019): Selective vinylogous reactivity of carbene intermediate in gold-catalyzed alkyne carbocyclization: synthesis of indenols

11) C. Zhang, K. Hong, S. Dong, C. Pei, X. Zhang, C. He, W. Hu,* X. Xu* iScience 21, 499 (2019): Gold(I)-catalyzed aromatization: expeditious synthesis of polyfunctionalized naphthalenes

10) X. Tian, L. Song, C. Han, C. Zhang, Y. Wu, M. Rudolph, F. Rominger, A. S. K. Hashmi,* Org. Lett. 21, 2937 (2019): Gold(III)-Catalyzed Formal [3 + 2] Annulations of N-Acyl Sulfilimines with Ynamides for the Synthesis of 4-Aminooxazoles

9) C. Zhang, S. Chang, S. Dong, L. Qiu,* X. Xu* J. Org. Chem. 83, 9125 (2018): Acid-Promoted Bicyclization of Diaryl Alkynes: Synthesis of 2H-Indazoles with in Situ Generated Diazonium Salt as Nitrogen Source

8) C. Zhang, S. Dong, Y. Zheng, C. He, J. Chen, J. Zhen, L. Qiu,* X. Xu* Org. Biomol. Chem. 16, 688 (2018): Synthesis of Spiro-4H-Pyrazole-Oxindoles and Fused 1H-pyrazoles via Divergent, Thermally Induced Tandem Cyclization/Migration of Alkyne-Tethered Diazo Compounds

7) C. Pei, C. Zhang, Y. Qian, X. Xu* Org. Biomol. Chem. 16, 8677 (2018): Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

6) J. Cai, B.Wu, G. Rong, C. Zhang, L. Qiu,* X. Xu* Org. Lett. 20, 2733 (2018): Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused Indole and Spirooxindole Derivatives

5) C. Zhang, S. Chang, L. Qiu, X. Xu* Chem. Commun. 52, 12470 (2016): Chemodivergent Synthesis of Multi-substituted/Fused Pyrroles via Copper-Catalyzed Carbene Cascade Reaction of Propargyl α-Iminodiazoacetates

4) C. Zhang, J. Huang, L. Qiu,* X. Xu* Org. Lett., 18, 6208 (2016): Thermally Induced [3 + 2] Cycloaddition of Alkynyl-Tethered Diazoamides: Synthetic and Mechanistic Insights

3) X. Wang, K. Dong, B. Yan, C. Zhang, L. Qiu, X. Xu* RSC adv. 6, 70221 (2016): NBS-mediated dinitrogen extrusion of diazoacetamides under catalyst-free conditions: practical access to 3-bromooxindole derivatives

2) X. Wang, Y. Zhou, L. Qiu, R. Yao, Y. Zheng, C. Zhang, X. Bao, X. Xu* Adv. Synth. Catal. 358, 1571 (2016): Enantioselective Carbene Cascade: An Effective Approach to Cyclopentadienes and Applications in Diels–Alder Reactions

1) J. Chen, J. Mao, Y. Zheng, D. Liu, G. Rong, H. Yan, C Zhang, D Shi* Tetrahedron 71, 5059 (2015): Iodine-promoted decarboxylative C–S cross-coupling of cinnamic acids with sodium benzene sulfinates